MSH2 (NM_000251) Human Recombinant Protein
Product Specifications
Background
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Overview
Purified recombinant protein of Human mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2), Tyr121-Ile169-GGGGS-Pro837-Lys907, with N-terminal His tag, expressed in E.coli, 50ug
Synonyms
COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; MMRCS2
Gene ID
4436
UniProt
P43246
Accession Number mRNA
NM_000251
Chromosomal Location
2p21-p16.3
Expression System
E. coli
Tag
N-His
Related Pathways
Colorectal cancer, Mismatch repair, Pathways in cancer
Field of Research
Colorectal cancer, Mismatch repair, Pathways in cancer
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol
Function
Druggable Genome, Stem cell - Pluripotency
Molecular Weight
13.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MSH2
Species
Human
Protein ID
NP_000242
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4436
Uniprot URL
https://www.uniprot.org/uniprot/P43246
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000251
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000242
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