IRE1 (ERN2) (NM_033266) Human Recombinant Protein
Product Specifications
Background
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Human endoplasmic reticulum to nucleus signaling 2 (ERN2), Asp320-Asp617, with N-terminal His tag, expressed in E.coli, 50ug
Synonyms
HIRE2p; IRE1-BETA; IRE1b; IRE2p
Gene ID
10595
UniProt
Q76MJ5, A5YM46, A5YM65
Accession Number mRNA
NM_033266
Chromosomal Location
16p12.2
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
>80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea
Function
Druggable Genome, Protein Kinase
Molecular Weight
32.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ERN2
Species
Human
Protein ID
NP_150296
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/10595
Uniprot URL
https://www.uniprot.org/uniprot/Q76MJ5
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_033266
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_150296
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