TLR9 (NM_017442) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017]

Overview

Purified recombinant protein of Human toll-like receptor 9 (TLR9), Leu26-Asn300, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

CD289

Gene ID

54106

UniProt

Q9NR96

Accession Number mRNA

NM_017442

Chromosomal Location

3p21.2

Expression System

E. coli

Tag

N-His

Related Pathways

Toll-like receptor signaling pathway

Field of Research

Toll-like receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

>80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Druggable Genome, Transmembrane

Molecular Weight

30.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.