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IL3RA (NM_002183) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5) . The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]

Overview

Purified recombinant protein of Human interleukin 3 receptor, alpha (low affinity) (IL3RA), Thr19-Arg305, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

CD123; hIL-3Ra; IL3R; IL3RAY; IL3RX; IL3RY

Gene ID

3563

UniProt

P26951

Accession Number mRNA

NM_002183

Chromosomal Location

X; Y

Expression System

E. coli

Tag

N-His

Related Pathways

Apoptosis, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

Field of Research

Apoptosis, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

>80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Transmembrane

Molecular Weight

33.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

IL3RA

Species

Human

Protein ID

NP_002174

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3563

Uniprot URL

https://www.uniprot.org/uniprot/P26951

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002183

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002174

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