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TIA1 (NM_022173) Human Recombinant Protein

Product Specifications

Background

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]

Overview

Purified recombinant protein of Human TIA1 cytotoxic granule-associated RNA binding protein (TIA1), transcript variant 2, Val279-End, with N-terminal His tag, expressed in E.coli, 50ug

Synonyms

ALS26; TIA-1; WDM

Gene ID

7072

UniProt

P31483

Accession Number mRNA

NM_022173

Chromosomal Location

2p13.3

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

>80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea

Function

Druggable Genome

Molecular Weight

12.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

TIA1

Species

Human

Protein ID

NP_071505

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/7072

Uniprot URL

https://www.uniprot.org/uniprot/P31483

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_022173

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_071505

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