TIA1 (NM_022173) Human Recombinant Protein
Product Specifications
Background
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly (A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017]
Synonyms
ALS26; TIA-1; WDM
Gene ID
7072
UniProt
P31483
Accession Number mRNA
NM_022173
Chromosomal Location
2p13.3
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
>80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea
Function
Druggable Genome
Molecular Weight
12.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TIA1
Species
Human
Protein ID
NP_071505
Overview
Purified recombinant protein of Human TIA1 cytotoxic granule-associated RNA binding protein (TIA1), transcript variant 2, Val279-End, with N-terminal His tag, expressed in E.coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7072
Uniprot URL
https://www.uniprot.org/uniprot/P31483
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022173
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_071505
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