Neurofilament (NEFL) (NM_006158) Human Recombinant Protein
Product Specifications
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
Overview
Purified recombinant protein of Human neurofilament, light polypeptide (NEFL), Ser2-Glu90, with N-terminal His tag, expressed in E.coli, 50ug
Synonyms
CMT1F; CMT2E; CMTDIG; NF-L; NF68; NFL; PPP1R110
Gene ID
4747
UniProt
P07196
Accession Number mRNA
NM_006158
Chromosomal Location
8p21.2
Expression System
E. coli
Tag
N-His
Related Pathways
Amyotrophic lateral sclerosis (ALS)
Field of Research
Amyotrophic lateral sclerosis (ALS)
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
>80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea
Function
Druggable Genome, ES Cell Differentiation/IPS
Molecular Weight
9.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NEFL
Species
Human
Protein ID
NP_006149
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4747
Uniprot URL
https://www.uniprot.org/uniprot/P07196
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_006158
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_006149
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