T-0156 (free base)

T-0156 free base is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 free base specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM) . T-0156 free base inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM) . T-0156 free base enhances the nitric oxide (NO) /cGMP pathway[1].

Product Specifications

CAS Number

[324572-92-1]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/t-0156-free-base.html

Smiles

O=C(C1=C(C2=CC(OC)=C(OC)C(OC)=C2)C3=CC=NC(OCC4=NC=CC=N4)=C3C(N1CC5=CC(C)=NC=C5)=O)OC

Molecular Formula

C31H29N5O7

Molecular Weight

583.59

References & Citations

[1]Hideki Mochida, et al. Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor. Eur J Pharmacol. 2002 Dec 5;456 (1-3) :91-8.