Psenen (NM_025498) Mouse Recombinant Protein
Product Specifications
Background
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:24941111) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable) . PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:24941111) .[UniProtKB/Swiss-Prot Function]
Synonyms
1700023M09Rik; Pen-2
Gene ID
66340
UniProt
Q9CQR7
Accession Number mRNA
NM_025498
Chromosomal Location
7 B1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
12 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Psenen
Species
Mouse
Protein ID
NP_079774
Overview
Purified recombinant protein of Mouse presenilin enhancer gamma secretase subunit (Psenen), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/66340
Uniprot URL
https://www.uniprot.org/uniprot/Q9CQR7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_025498
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_079774
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