Fkbp1a (NM_008019) Mouse Recombinant Protein
Product Specifications
Background
This gene is a member of the immunophilin family. The encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, and is associated with immunoregulation, protein folding, receptor signaling, protein trafficking and T-cell activation. It may modulate the calcium release activity of the ryanodine receptor Ryr1. It also interacts with the type I TGF-beta receptor. Disruption of this gene in mouse causes severe ventricular defects. Pseudogenes of this gene have been defined on chromosomes 4, 10, 14, and 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Synonyms
Fkb; Fkbp; Fkbp1; FKBP12
Gene ID
14225
UniProt
P26883
Accession Number mRNA
NM_008019
Chromosomal Location
2 G3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
11.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Fkbp1a
Species
Mouse
Protein ID
NP_032045
Overview
Purified recombinant protein of Mouse FK506 binding protein 1a (Fkbp1a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/14225
Uniprot URL
https://www.uniprot.org/uniprot/P26883
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_008019
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_032045
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