Polr3k (NM_025901) Mouse Recombinant Protein
Product Specifications
Background
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
12.3kDa; 1500004O14Rik; AI196849; AU014893; C11; RPC10; RPC11
Gene ID
67005
UniProt
Q9CQZ7, Q3TSW1
Accession Number mRNA
NM_025901
Chromosomal Location
2 H4
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
12.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Polr3k
Species
Mouse
Protein ID
NP_080177
Overview
Purified recombinant protein of Mouse polymerase (RNA) III (DNA directed) polypeptide K (Polr3k), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/67005
Uniprot URL
https://www.uniprot.org/uniprot/Q9CQZ7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_025901
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_080177
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