Tyrobp (NM_011662) Mouse Recombinant Protein

Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (PubMed:15471863, PubMed:9647200) . TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (PubMed:15728241) . Also has an inhibitory role in some cells (PubMed:21727189) . Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity) . Also mediates cell activation through association with activating receptors of the CD200R family (PubMed:15471863) . Required for neutrophil activation mediated by integrin (PubMed:17086186) . Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity) . Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity) . Also associates non-covalently with the NK cell receptors KLRA4/LY49D and KLRA8/LY49H which leads to NK cell activation (PubMed:9647200) . Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity) . Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity) . Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (PubMed:18957693) . Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) which is produced by TREM2 ectodomain shedding (By similarity) . In microglia, required with TREM2 for phagocytosis of apoptotic neurons (PubMed:15728241) . Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (PubMed:18685038) . Promotes proinflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (PubMed:25690660) . Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allostimulatory ability (PubMed:21257958) . Negatively regulates B cell proliferation (PubMed:21727189) . Required for CSF1-mediated osteoclast cytoskeletal organization (PubMed:18691974) . Positively regulates multinucleation during osteoclast development (PubMed:12569157, PubMed:14969392) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Mouse TYRO protein tyrosine kinase binding protein (Tyrobp), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.