Elob (NM_026305) Mouse Recombinant Protein
Product Specifications
Background
SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity) . In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (PubMed:27863225, PubMed:27863226) .[UniProtKB/Swiss-Prot Function]
Synonyms
0610040H15Rik; Tceb2
Gene ID
67673
UniProt
P62869
Accession Number mRNA
NM_026305
Chromosomal Location
17 A3.3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
13.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Elob
Species
Mouse
Protein ID
NP_080581
Overview
Purified recombinant protein of Mouse elongin B (Elob), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/67673
Uniprot URL
https://www.uniprot.org/uniprot/P62869
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_026305
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_080581
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