Ube2d2a (NM_019912) Mouse Recombinant Protein
Product Specifications
Background
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.[UniProtKB/Swiss-Prot Function]
Synonyms
1500034D03Rik; Ubc2e; ubc4; Ube2d2
Gene ID
56550
UniProt
P62838, Q3UT95
Accession Number mRNA
NM_019912
Chromosomal Location
18 B2
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
16.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Ube2d2a
Species
Mouse
Protein ID
NP_064296
Overview
Purified recombinant protein of Mouse ubiquitin-conjugating enzyme E2D 2A (Ube2d2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/56550
Uniprot URL
https://www.uniprot.org/uniprot/P62838
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_019912
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_064296
Curated Selection
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