Cplx3 (NM_146223) Mouse Recombinant Protein

Product Specifications

Background

Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896) . Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896) . Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398) . Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca (2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca (2+) vesicle release (PubMed:22694764, PubMed:27335398) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse complexin 3 (Cplx3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

BC016632; CpxIII; ERGIC-53L; ERGL; Lamn1l; Lman1l

Gene ID

235415

UniProt

Q8R1B5

Accession Number mRNA

NM_146223

Chromosomal Location

9 B

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

17.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.