Cplx4 (NM_145493) Mouse Recombinant Protein

Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896) . Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896) . Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398) . Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca (2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca (2+) vesicle release (PubMed:22694764, PubMed:27335398) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.