Cdkn2c (NM_007671) Mouse Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase (cdk) inhibitors, and contains five ankyrin repeats. This protein interacts with both Cdk4 and Cdk6 to inhibit their kinase activities, and prevent their interactions with D-type cyclins, thereby negatively regulating cell division. This gene is differentially expressed in a variety of tissues, and is cell cycle regulated. Deletion of this gene can lead to tumor growth. Maximal expression is observed at the G2/M phase. Alternative splicing and promoter usage results in multiple transript variants. [provided by RefSeq, Aug 2014]
Overview
Purified recombinant protein of Mouse cyclin dependent kinase inhibitor 2C (Cdkn2c), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
C77269; INK; INK4c; p1; p18; p18-INK4c; p18-INK6; p18IN; p18INK4c
Gene ID
12580
UniProt
Q60772, Q9D153
Accession Number mRNA
NM_007671
Chromosomal Location
4 51.32 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
18.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Cdkn2c
Species
Mouse
Protein ID
NP_031697
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/12580
Uniprot URL
https://www.uniprot.org/uniprot/Q60772
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_007671
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_031697
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