Nudt15 (NM_172527) Mouse Recombinant Protein

May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:12767940) . Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (By similarity) . Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:12767940) . Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (By similarity) . May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (By similarity) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Purified recombinant protein of Mouse nudix (nucleoside diphosphate linked moiety X) -type motif 15 (Nudt15), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug