Nenf (NM_025424) Mouse Recombinant Protein

Acts as a neurotrophic factor in postnatal mature neurons, enhancing neuronal survival (PubMed:15605373) . Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte (PubMed:16547973) . Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (PubMed:15605373, PubMed:16547973) . Neurotrophic activity is enhanced by binding to heme (PubMed:18056703) . Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (PubMed:23576617) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.