Arl6 (NM_019665) Mouse Recombinant Protein

Involved in membrane protein trafficking at the base of the ciliary organelle (By similarity) . Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity) . Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (PubMed:24939912) . Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (By similarity) . May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (By similarity) . Isoform 2 may be required for proper retinal function and organization (PubMed:20333246) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.