Cbx5 (NM_001110216) Mouse Recombinant Protein
Selected Variant
PM48463M5
Size: 20 µg
Product Specifications
Background
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) . Can interact with lamin-B receptor (LBR) . This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse chromobox 5 (Cbx5), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
2610029O15Rik; C75991; HP1; Hp1a; Hp1alpha
Gene ID
12419
UniProt
Q61686
Accession Number mRNA
NM_001110216
Chromosomal Location
15 F3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
22.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Cbx5
Species
Mouse
Protein ID
NP_001103686
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/12419
Uniprot URL
https://www.uniprot.org/uniprot/Q61686
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001110216
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001103686
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