Bax (NM_007527) Mouse Recombinant Protein
Product Specifications
Background
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse BCL2-associated X protein (Bax), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID
12028
UniProt
Q07813, Q544Z6
Accession Number mRNA
NM_007527
Chromosomal Location
7 29.32 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
21.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Bax
Species
Mouse
Protein ID
NP_031553
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/12028
Uniprot URL
https://www.uniprot.org/uniprot/Q07813
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_007527
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_031553
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