Rnf185 (BC014812) Mouse Recombinant Protein
Product Specifications
Background
E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER) -associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
MGC19394
Gene ID
193670
UniProt
Q91YT2
Accession Number mRNA
BC014812
Chromosomal Location
11 A1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
20.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Rnf185
Species
Mouse
Overview
Purified recombinant protein of Mouse ring finger protein 185 (cDNA clone MGC:19394 IMAGE:3153870), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/193670
Uniprot URL
https://www.uniprot.org/uniprot/Q91YT2
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC014812
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