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Gm2a (NM_010299) Mouse Recombinant Protein

Product Specifications

Background

Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse GM2 ganglioside activator protein (Gm2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

AA408702; AW215435; GM2-AP; SAP-3

Gene ID

14667

UniProt

Q60648, Q5F1Z8

Accession Number mRNA

NM_010299

Chromosomal Location

11 32.13 cM

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

20.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

Gm2a

Species

Mouse

Protein ID

NP_034429

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/14667

Uniprot URL

https://www.uniprot.org/uniprot/Q60648

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_010299

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_034429

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