Gm2a (NM_010299) Mouse Recombinant Protein
Product Specifications
Background
Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse GM2 ganglioside activator protein (Gm2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AA408702; AW215435; GM2-AP; SAP-3
Gene ID
14667
UniProt
Q60648, Q5F1Z8
Accession Number mRNA
NM_010299
Chromosomal Location
11 32.13 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
20.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Gm2a
Species
Mouse
Protein ID
NP_034429
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/14667
Uniprot URL
https://www.uniprot.org/uniprot/Q60648
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_010299
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_034429
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