Rd3 (NM_023727) Mouse Recombinant Protein

Product Specifications

Background

Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:21078983, PubMed:27471269) . Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:27471269) . Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983) . Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP (By similarity) . Plays an important role for the survival of rods and cones in the retina (PubMed:8486383, PubMed:17186464) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse retinal degeneration 3 (Rd3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

3322402L07Rik; rd-3

Gene ID

74023

UniProt

Q8BRE0

Accession Number mRNA

NM_023727

Chromosomal Location

1 97.09 cM

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

22.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.