Rd3 (NM_023727) Mouse Recombinant Protein
Product Specifications
Background
Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:21078983, PubMed:27471269) . Inhibits the basal catalytic activity and the GCAP-stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors (PubMed:27471269) . Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment (PubMed:21078983) . Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP (By similarity) . Plays an important role for the survival of rods and cones in the retina (PubMed:8486383, PubMed:17186464) .[UniProtKB/Swiss-Prot Function]
Synonyms
3322402L07Rik; rd-3
Gene ID
74023
UniProt
Q8BRE0
Accession Number mRNA
NM_023727
Chromosomal Location
1 97.09 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
22.7 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Rd3
Species
Mouse
Protein ID
NP_076216
Overview
Purified recombinant protein of Mouse retinal degeneration 3 (Rd3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/74023
Uniprot URL
https://www.uniprot.org/uniprot/Q8BRE0
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_023727
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_076216
Curated Selection
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