Kctd6 (NM_027782) Mouse Recombinant Protein
Product Specifications
Background
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) . Involved in regulating protein levels of ANK1 isoform Mu7 probably implicating CUL3-dependent proteasomal degradation.[UniProtKB/Swiss-Prot Function]
Synonyms
5430433B02Rik; AU044285
Gene ID
71393
UniProt
Q8BNL5, A2RS47
Accession Number mRNA
NM_027782
Chromosomal Location
14 A1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
27.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Kctd6
Species
Mouse
Protein ID
NP_082058
Overview
Purified recombinant protein of Mouse potassium channel tetramerisation domain containing 6 (Kctd6), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/71393
Uniprot URL
https://www.uniprot.org/uniprot/Q8BNL5
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_027782
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_082058
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
