Fcgr4 (NM_144559) Mouse Recombinant Protein

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578) . Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059) . Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417) . Can bind to IgG2a and IgG2b monomers (PubMed:18949059) . Does not display binding to IgG1 or IgG3 (PubMed:16039578) . Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064) . Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719) . Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059) . Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411) . Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059) . Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.