Gzma (NM_010370) Mouse Recombinant Protein
Product Specifications
Background
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
AW494114; Ctla-3; Ctla3; Hf; Hf1; SE1; TSP-1; TSP1
Gene ID
14938
UniProt
P11032, Q3U0N0
Accession Number mRNA
NM_010370
Chromosomal Location
13 63.93 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
29 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Gzma
Species
Mouse
Protein ID
NP_034500
Overview
Purified recombinant protein of Mouse granzyme A (Gzma), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/14938
Uniprot URL
https://www.uniprot.org/uniprot/P11032
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_010370
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_034500
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