Mettl1 (NM_010792) Mouse Recombinant Protein

Methyltransferase that mediates the formation of N (7) -methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:29983320) . Catalyzes the formation of N (7) -methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N (7) -methylguanine in mRNAs (PubMed:29983320) . Internal N (7) -methylguanine methylation of mRNAs regulates translation (PubMed:29983320) . Also methylates a specific subset of miRNAs, such as let-7. N (7) -methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (By similarity) . Acts as a regulator of embryonic stem cell self-renewal and differentiation (PubMed:29983320) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.