Itm2c (NM_022417) Mouse Recombinant Protein
Selected Variant
PM47730M5
Size: 20 µg
Product Specifications
Background
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse integral membrane protein 2C (Itm2c), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
3110038L02Rik; BRI3; Bricd2c; E25; E25C; ITM3
Gene ID
64294
UniProt
Q91VK4
Accession Number mRNA
NM_022417
Chromosomal Location
1 C5
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
30.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Itm2c
Species
Mouse
Protein ID
NP_071862
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/64294
Uniprot URL
https://www.uniprot.org/uniprot/Q91VK4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_022417
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_071862
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