Spsb4 (NM_145134) Mouse Recombinant Protein

Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) . Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity) . Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity) . Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of the EphB2/CTF2 (By similarity) . Regulates cellular clock function by mediating ubiquitination and proteasomal degradation of the circadian transcriptional repressor NR1D1 (By similarity) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Purified recombinant protein of Mouse splA/ryanodine receptor domain and SOCS box containing 4 (Spsb4), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug