Ctdspl (NM_133710) Mouse Recombinant Protein
Product Specifications
Background
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
2810418J22Rik; AI426263; HYA22; SCP3
Gene ID
69274
UniProt
P58465
Accession Number mRNA
NM_133710
Chromosomal Location
9 F3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
31.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Ctdspl
Species
Mouse
Protein ID
NP_598471
Overview
Purified recombinant protein of Mouse CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (Ctdspl), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/69274
Uniprot URL
https://www.uniprot.org/uniprot/P58465
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_133710
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_598471
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