Hes1 (NM_008235) Mouse Recombinant Protein
Product Specifications
Background
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity) . Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse hes family bHLH transcription factor 1 (Hes1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
BHLHb39; Hry
Gene ID
15205
UniProt
P35428, Q3UZZ2
Accession Number mRNA
NM_008235
Chromosomal Location
16 21.09 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
30.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Hes1
Species
Mouse
Protein ID
NP_032261
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/15205
Uniprot URL
https://www.uniprot.org/uniprot/P35428
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_008235
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_032261
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