Ercc1 (NM_007948) Mouse Recombinant Protein
Product Specifications
Background
Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL) . Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity) .[UniProtKB/Swiss-Prot Function]
Synonyms
Ercc-1
Gene ID
13870
UniProt
P07903, Q91VP3
Accession Number mRNA
NM_007948
Chromosomal Location
7 9.6 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
32.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Ercc1
Species
Mouse
Protein ID
NP_031974
Overview
Purified recombinant protein of Mouse excision repair cross-complementing rodent repair deficiency, complementation group 1 (Ercc1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/13870
Uniprot URL
https://www.uniprot.org/uniprot/P07903
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_007948
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_031974
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