Lgals8 (NM_018886) Mouse Recombinant Protein
Product Specifications
Background
Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans.[UniProtKB/Swiss-Prot Function]
Synonyms
1200015E08Rik; AI326142; D13Ertd524e; Lgals-8
Gene ID
56048
UniProt
Q9JL15, Q542M5
Accession Number mRNA
NM_018886
Chromosomal Location
13 4.64 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
36.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Lgals8
Species
Mouse
Protein ID
NP_061374
Overview
Purified recombinant protein of Mouse lectin, galactose binding, soluble 8 (Lgals8), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/56048
Uniprot URL
https://www.uniprot.org/uniprot/Q9JL15
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_018886
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_061374
Curated Selection
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