Icosl (NM_015790) Mouse Recombinant Protein
Product Specifications
Background
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.[UniProtKB/Swiss-Prot Function]
Synonyms
AU044799; B7-H2; B7h; B7RP-1; BG071784; GI50; GL50; GL50-B; ICOS-L; Icoslg; LICOS; Ly115l
Gene ID
50723
UniProt
Q9JHJ8, Q544C7
Accession Number mRNA
NM_015790
Chromosomal Location
10 C1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
36 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Icosl
Species
Mouse
Protein ID
NP_056605
Overview
Purified recombinant protein of Mouse icos ligand (Icosl), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/50723
Uniprot URL
https://www.uniprot.org/uniprot/Q9JHJ8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015790
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_056605
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