Hmgcl (NM_008254) Mouse Recombinant Protein
Product Specifications
Background
Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S) -3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AW476067; HL
Gene ID
15356
UniProt
P38060
Accession Number mRNA
NM_008254
Chromosomal Location
4 68.14 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
34.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Hmgcl
Species
Mouse
Protein ID
NP_032280
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/15356
Uniprot URL
https://www.uniprot.org/uniprot/P38060
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_008254
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_032280
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