Xrcc4 (NM_028012) Mouse Recombinant Protein
Product Specifications
Background
Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V (D) J recombination. Binds to DNA and to DNA ligase IV (LIG4) . The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse X-ray repair complementing defective repair in Chinese hamster cells 4 (Xrcc4), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
2310057B22Rik; AW413319; AW545101
Gene ID
108138
UniProt
Q924T3, A0A0R4J024
Accession Number mRNA
NM_028012
Chromosomal Location
13 C3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
37.1 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Xrcc4
Species
Mouse
Protein ID
NP_082288
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/108138
Uniprot URL
https://www.uniprot.org/uniprot/Q924T3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_028012
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_082288
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