Mgme1 (NM_028984) Mouse Recombinant Protein
Product Specifications
Background
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair (By similarity) . Specifically binds 5-hydroxymethylcytosine (5hmC) -containing DNA in stem cells.[UniProtKB/Swiss-Prot Function]
Synonyms
8430406I07Rik; AI426476
Gene ID
74528
UniProt
Q9CXC3
Accession Number mRNA
NM_028984
Chromosomal Location
2 G1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
38.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Mgme1
Species
Mouse
Protein ID
NP_083260
Overview
Purified recombinant protein of Mouse mitochondrial genome maintenance exonuclease 1 (Mgme1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/74528
Uniprot URL
https://www.uniprot.org/uniprot/Q9CXC3
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_028984
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_083260
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