Dkk3 (NM_015814) Mouse Recombinant Protein
Product Specifications
Background
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse dickkopf WNT signaling pathway inhibitor 3 (Dkk3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AW061014; C87148; dkk-3; mDkk-3
Gene ID
50781
UniProt
Q9QUN9
Accession Number mRNA
NM_015814
Chromosomal Location
7 F1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
38.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Dkk3
Species
Mouse
Protein ID
NP_056629
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/50781
Uniprot URL
https://www.uniprot.org/uniprot/Q9QUN9
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015814
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_056629
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