Polr2m (NM_001164793) Mouse Recombinant Protein

Isoform 1 appears to be stable component of the Pol II (G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in Mediator-dependent regulation of transcription activation. Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II (G) activator-dependent transcription to a level equivalent to that of Pol II (By similarity) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Mouse polymerase (RNA) II (DNA directed) polypeptide M (Polr2m), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.