Kcnab2 (NM_010598) Mouse Recombinant Protein

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:8576199) . Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (PubMed:11825900, PubMed:21209188) . Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity) . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:8576199) . Modulates the functional properties of KCNA4 (By similarity) . Modulates the functional properties of KCNA5 (PubMed:8576199) . Enhances KCNB2 channel activity (PubMed:8824288) . Modulates the functional properties of KCNA5 (PubMed:8576199) . Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity) . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity) .[UniProtKB/Swiss-Prot Function]

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Purified recombinant protein of Mouse potassium voltage-gated channel, shaker-related subfamily, beta member 2 (Kcnab2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug