Sox18 (NM_009236) Mouse Recombinant Protein
Product Specifications
Background
Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis (PubMed:7651823, PubMed:10742113, PubMed:12748961, PubMed:18931657, PubMed:19429912, PubMed:26939885) . Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers (PubMed:18931657, PubMed:26939885) . Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells (PubMed:18931657) . Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17 (PubMed:16895970) . Interaction with MEF2C enhances transcriptional activation (PubMed:11554755) . Besides, required for normal hair development (PubMed:11094083, PubMed:12748961) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse SRY (sex determining region Y) -box 18 (Sox18), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AI385749; Ra; Ragl
Gene ID
20672
UniProt
P43680
Accession Number mRNA
NM_009236
Chromosomal Location
2 103.71 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
41.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Sox18
Species
Mouse
Protein ID
NP_033262
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/20672
Uniprot URL
https://www.uniprot.org/uniprot/P43680
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_009236
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_033262
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