Wnt5a (NM_009524) Mouse Recombinant Protein

Ligand for members of the frizzled family of seven transmembrane receptors (PubMed:17117926) . Can activate or inhibit canonical Wnt signaling, depending on receptor context (PubMed:16602827) . In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (PubMed:16602827) . Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration (PubMed:17117926) . Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity) . Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle (PubMed:10021340) . Inhibits type II collagen expression in chondrocytes (By similarity) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Mouse wingless-type MMTV integration site family, member 5A (Wnt5a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.