Tnfrsf10b (NM_020275) Mouse Recombinant Protein

Product Specifications

Background

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse tumor necrosis factor receptor superfamily, member 10b (Tnfrsf10b), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A; TRICK2B; TRICKB

Gene ID

21933

UniProt

Q9QZM4

Accession Number mRNA

NM_020275

Chromosomal Location

14 D2

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

42.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.