Cipc (NM_173735) Mouse Recombinant Protein

Product Specifications

Background

Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK (PubMed:17310242, PubMed:19414601) . However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock (PubMed:25862660) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse CLOCK interacting protein, circadian (Cipc), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

2310044G17Rik; AI842544; AI853744; Kiaa1737; mKIAA1737

Gene ID

217732

UniProt

Q8R0W1, Z4YJJ0

Accession Number mRNA

NM_173735

Chromosomal Location

12 D2

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

42.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.