Itfg2 (NM_133927) Mouse Recombinant Protein
Product Specifications
Background
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.[UniProtKB/Swiss-Prot Function]
Synonyms
2700050P07Rik; AI646725
Gene ID
101142
UniProt
Q91WI7
Accession Number mRNA
NM_133927
Chromosomal Location
6 F3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
49 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Itfg2
Species
Mouse
Protein ID
NP_598688
Overview
Purified recombinant protein of Mouse integrin alpha FG-GAP repeat containing 2 (Itfg2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/101142
Uniprot URL
https://www.uniprot.org/uniprot/Q91WI7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_133927
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_598688
Curated Selection
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