Smpdl3b (NM_133888) Mouse Recombinant Protein
Product Specifications
Background
Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity (PubMed:26095358) . Acts as a negative regulator of Toll-like receptor signaling (PubMed:26095358, PubMed:27687724) . Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358, PubMed:27687724) . Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (PubMed:27687724) .[UniProtKB/Swiss-Prot Function]
Synonyms
1110054A24Rik; Asml3b; AU045240
Gene ID
100340
UniProt
P58242, Q3TLX9
Accession Number mRNA
NM_133888
Chromosomal Location
4 D2.3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
51.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Smpdl3b
Species
Mouse
Protein ID
NP_598649
Overview
Purified recombinant protein of Mouse sphingomyelin phosphodiesterase, acid-like 3B (Smpdl3b), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/100340
Uniprot URL
https://www.uniprot.org/uniprot/P58242
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_133888
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_598649
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