Smpdl3b (NM_133888) Mouse Recombinant Protein

Product Specifications

Background

Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity (PubMed:26095358) . Acts as a negative regulator of Toll-like receptor signaling (PubMed:26095358, PubMed:27687724) . Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358, PubMed:27687724) . Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (PubMed:27687724) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse sphingomyelin phosphodiesterase, acid-like 3B (Smpdl3b), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

1110054A24Rik; Asml3b; AU045240

Gene ID

100340

UniProt

P58242, Q3TLX9

Accession Number mRNA

NM_133888

Chromosomal Location

4 D2.3

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

51.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.