Frmd8 (NM_026169) Mouse Recombinant Protein
Selected Variant
PM46196M5
Size: 20 µg
Product Specifications
Background
Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333) . By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity) . Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse FERM domain containing 8 (Frmd8), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
1200004M23Rik; 2310035N23Rik; 4931429L16Rik; AU018809
Gene ID
67457
UniProt
Q3UFK8
Accession Number mRNA
NM_026169
Chromosomal Location
19 A
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
51.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Frmd8
Species
Mouse
Protein ID
NP_080445
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/67457
Uniprot URL
https://www.uniprot.org/uniprot/Q3UFK8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_026169
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_080445
Price
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